What to know about ketamine therapy after Matthew Perry's cause of death announced

Friends Actor Died of 'Acute Effects of Ketamine.The Friends actor died due to acute effects of ketamine, according to an autopsy report obtained by PEOPLE. Drowning, coronary artery disease and buprenorphine effects (a medication used to treat opioid use disorder) were also listed as contributing factors in his death, which was ruled accidental.

Ketamine is a "dissociative anesthetic that has some hallucinogenic effects," per the US Drug Enforcement Administration.

The autopsy states that Perry — who was "reportedly clean for 19 months" — was on ketamine infusion therapy, with his latest treatment taking place just "one and a half weeks before" his death.